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KMID : 0370220090530060351
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Yakhak Hoeji
2009 Volume.53 No. 6 p.351 ~ p.356
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Studies on the Antiinflammatory Compounds from Sorbus Commixta
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Yun Young-Gab
Chai Kyu-Yun
Lee Kyung-Kwan
Lok Ranjan Bhatt
Baek Seung-Hwa
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Abstract
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Sakuranetin, prunetin and dihydroquercetin were isolated from the methanol extract of Sorbus commixta by 1D/2D-NMR and LC-MASS spectrometry. Medicating these compounds to RAW264.7 cell that was pre-treated by lipopolysaccharide revealed anti-inflammatory effects that greatly inhibited the production of NO (nitric oxide) and PEG2 (prostaglandin E2), which are well known to cause the expression of iNOS (inducible nitric oxide synthase) and COX-2 (Cyclooxygenase-2). These results suggest that these compounds can be used as stable anti-inflammatory materials.
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KEYWORD
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Sorbus commixta, sakuranetin, prunetin, dihydroquercetin, anti-inflammatory effects, NO, PEG2
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